منابع مشابه
An end for mismatch repair.
D NA mismatch repair (MMR) is an important postreplicative repair mechanism that removes DNA polymerization errors and is responsible for increasing the fidelity of genome replication by orders of magnitude. Defects in MMR lead to the most common form of hereditary colon cancer and a variety of sporadic cancers (1–3). One of the main features of MMR is its ability to distinguish old and new DNA...
متن کاملDNA mismatch repair.
DNA mismatch repair (MMR) is an evolutionarily conserved process that corrects mismatches generated during DNA replication and escape proofreading. MMR proteins also participate in many other DNA transactions, such that inactivation of MMR can have wide-ranging biological consequences, which can be either beneficial or detrimental. We begin this review by briefly considering the multiple functi...
متن کاملSnapShot: DNA Mismatch Repair
Mismatch Repair in Bacteria and Eukaryotes Mismatch repair in the bacterium Escherichia coli is initiated when a homodimer of MutS binds as an asymmetric clamp to DNA containing a variety of base-base and insertion-deletion mismatches. The MutL homodimer then couples MutS recognition to the signal that distinguishes between the template and nascent DNA strands. In E. coli, the lack of adenine m...
متن کاملMismatch repair: praying for genome stability
For the reader who believes that only computers can faithfully duplicate gigabits of information, some insights into his or her own biology will be revealing. Just as he or she reads this Primer, billions of his or her cells prepare for division by replicating the six billion or so DNA nucleotides of their diploid genomes, each cell typically making not more than a single mistake. This extraord...
متن کاملMismatch repair: Origin of species?
Mismatch repair reverses replication errors and inhibits recombination between diverged sequences. This has been suggested to be important in speciation, especially in prokaryotes, but theoretical analysis indicates that genetic divergence in bacterial populations is not constrained by naturally occurring recombination levels.
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2010
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1016039107